BDBM324377 (R)-1-(tert-butyl)-N-(8- (2-((1,3-dimethyl-1H- pyrazol-4- yl)amino)pyrimidin-4- yl)-2-(oxetan-3-yl)- 2,3,4,5-tetrahydro-1H- benzo[c]azepin- 5-yl)-1H- 1,2,3-triazole-4- carboxamide::US10189829, Compound 103::US10227341, Compound 103::US10961237, Compound 103::US11858926, Compound 103

SMILES Cc1nn(C)cc1Nc1nccc(n1)-c1ccc2[C@@H](CCN(Cc2c1)C1COC1)NC(=O)c1cn(nn1)C(C)(C)C

InChI Key InChIKey=OEKCBUGDRLQPDI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 324377   

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324377((R)-1-(tert-butyl)-N-(8- (2-((1,3-dimethyl-1H- pyr...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324377((R)-1-(tert-butyl)-N-(8- (2-((1,3-dimethyl-1H- pyr...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324377((R)-1-(tert-butyl)-N-(8- (2-((1,3-dimethyl-1H- pyr...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [14-552](Human)
Biogen Ma

US Patent
LigandPNGBDBM324377((R)-1-(tert-butyl)-N-(8- (2-((1,3-dimethyl-1H- pyr...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
US Patent