BDBM324385 1-(tert-butyl)-N-(7- (2-((1- methyl-1H-pyrazol-4- yl)amino)pyrimidin-4- yl)-3-(oxetan-3-yl)- 2,3,4,5-tetrahydro-1H- benzo[d]azepin- 1-yl)-1H- 1,2,3-triazole-4- carboxamide::US10189829, Compound 130::US10227341, Compound 130::US10961237, Compound 130::US11858926, Compound 130

SMILES Cn1cc(Nc2nccc(n2)-c2ccc3C(CN(CCc3c2)C2COC2)NC(=O)c2cn(nn2)C(C)(C)C)cn1

InChI Key InChIKey=COPVPMKQPMWKRD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 324385   

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324385(1-(tert-butyl)-N-(7- (2-((1- methyl-1H-pyrazol-4- ...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [14-552](Human)
Biogen Ma

US Patent
LigandPNGBDBM324385(1-(tert-butyl)-N-(7- (2-((1- methyl-1H-pyrazol-4- ...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324385(1-(tert-butyl)-N-(7- (2-((1- methyl-1H-pyrazol-4- ...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324385(1-(tert-butyl)-N-(7- (2-((1- methyl-1H-pyrazol-4- ...)
Affinity DataIC50: 5.5nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent