BDBM325471 US10189845, Example 133B

SMILES CCC(CC)n5cc(c3nc(c2cnn([C@@H]1C[C@@H](O)[C@@H](O)C1)c2)cn4nccc34)cn5

InChI Key InChIKey=GBHCHXVAULPBEL-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 325471   

TargetTyrosine-protein kinase JAK2(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 325471BDBM325471(US10189845, Example 133B)
Affinity DataIC50: 10nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 325471BDBM325471(US10189845, Example 133B)
Affinity DataIC50: 55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit Tyk2 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 325471BDBM325471(US10189845, Example 133B)
Affinity DataIC50: 55nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK1 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Array Biopharma

US Patent
LigandChemical structure of BindingDB Monomer ID 325471BDBM325471(US10189845, Example 133B)
Affinity DataIC50: 5.50E+3nMAssay Description:Compounds of Formula I were screened for their ability to inhibit JAK3 using the general enzyme inhibition assay method, in which the assay mixture c...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent