BDBM326245 (E)-N-(3-(6-amino-8-oxo-7-(6-phenoxypyridin-3-yl)-7H-purin-9(8H)-yl)phenyl)-4-(cyclopropyl(methyl)amino)-N-methylbut-2-enamide ::US9637487, Compound 49

SMILES CN(C\C=C\C(=O)N(C)c1cccc(c1)-n1c2ncnc(N)c2n(-c2ccc(Oc3ccccc3)nc2)c1=O)C1CC1

InChI Key InChIKey=YAVTUAJFXLTWDF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326245   

TargetTyrosine-protein kinase BTK(Human)
Pharmacyclics

US Patent
LigandPNGBDBM326245((E)-N-(3-(6-amino-8-oxo-7-(6-phenoxypyridin-3-yl)-...)
Affinity DataIC50: 100nMAssay Description:Human Btk kinase (Genbank accession # NP_000052) was purified from insect cells as a full-length construct containing a N-terminal 6×-His tag. Btk ki...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2019
Entry Details
US Patent