BDBM326289 (R)-4-((1- cyclobutylethyl) amino)- 6-(m-tolyl)-5-(4- (trifluoromethyl) benzyl)-5H-pyrrolo [3, 2-d] pyrimidine-2- carboxylic acid::US9637493, 1.3

SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)(F)F)c12)C(O)=O)C1CCC1

InChI Key InChIKey=WLLKNSQMTNCFQR-QGZVFWFLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326289   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326289((R)-4-((1- cyclobutylethyl) amino)- 6-(m-tolyl)-5-...)
Affinity DataIC50:  140nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent