BDBM326307 4-{[(1R)-1- cyclobutylethyl]amino}- 5-[4- (difluoromethyl)benzyl]- 6-(3-methylphenyl)-5H- pyrrolo[3,2- d]pyrimidine-2- carboxylic acid::US9637493, 3.2

SMILES C[C@@H](Nc1nc(nc2cc(-c3cccc(C)c3)n(Cc3ccc(cc3)C(F)F)c12)C(O)=O)C1CCC1

InChI Key InChIKey=WVSWWNXETLELNQ-QGZVFWFLSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 326307   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM326307(4-{[(1R)-1- cyclobutylethyl]amino}- 5-[4- (difluor...)
Affinity DataIC50:  530nMAssay Description:Methods: An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent