BDBM327861 8-tert-butyl-4-[2- (hydroxymethyl)-3-[1- methyl-5-[(5- methylsulfonylpyridin- 2-yl)amino]-6- oxopyridazin-3- yl]phenyl]-2,3- dihydro-1,4- benzoxazepin-5-one::US9663494, Compound 9

SMILES Cn1nc(cc(Nc2ccc(cn2)S(C)(=O)=O)c1=O)-c1cccc(N2CCOc3cc(ccc3C2=O)C(C)(C)C)c1CO

InChI Key InChIKey=HJKOWHLNZNGWOM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 327861   

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM327861(8-tert-butyl-4-[2- (hydroxymethyl)-3-[1- methyl-5-...)
Affinity DataIC50: 4.24nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of BTK, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent