BDBM329000 1137478-46-6::US11787792, Compound Y-153::US9663503, Compound Y-153

SMILES CC(C)(O)C#Cc1cnc(Nc2cnc(cn2)C#N)cc1NC[C@@H]1CNCCO1

InChI Key InChIKey=IDZXROKRAQBADP-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 329000   

TargetSerine/threonine-protein kinase Chk1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 4nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 4nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 180nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2A6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sareum

Curated by ChEMBL
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandPNGBDBM329000(US9663503, Compound Y-153 | 1137478-46-6 | US11787...)
Affinity DataIC50: 2.60E+4nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed