BDBM329200 4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluoro-5-::4-(5-chloro-6-(cyclobutyloxy)-3-pyridinyl)-2-fluoro-5-methoxy-N-(methylsulfonyl)benzamide::US9663508, Example 702

SMILES COc1cc(C(=O)NS(C)(=O)=O)c(F)cc1-c1cnc(OC2CCC2)c(Cl)c1

InChI Key InChIKey=DGHAHFNJROJTII-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 329200   

LigandPNGBDBM329200(US9663508, Example 702 | 4-(5-chloro-6-(cyclobutyl...)
Affinity DataIC50: 68.4nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

LigandPNGBDBM329200(US9663508, Example 702 | 4-(5-chloro-6-(cyclobutyl...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM329200(US9663508, Example 702 | 4-(5-chloro-6-(cyclobutyl...)
Affinity DataIC50: 4.90E+3nMAssay Description:293 cells stably transfected with human Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

LigandPNGBDBM329200(US9663508, Example 702 | 4-(5-chloro-6-(cyclobutyl...)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed