BDBM329930 US9663526, Example 13

SMILES CCNC(=O)c1ccc(Nc2nccc(N3C[C@H]4CC[C@@H](C3)N4C(=O)CC#N)n2)cc1

InChI Key InChIKey=GJCRLBVUCZFFSC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 329930   

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 329930BDBM329930(US9663526, Example 13)
Affinity DataIC50: 12nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 329930BDBM329930(US9663526, Example 13)
Affinity DataIC50: 41nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 329930BDBM329930(US9663526, Example 13)
Affinity DataIC50: 199nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 329930BDBM329930(US9663526, Example 13)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent