BDBM330067 (R)-2-amino-N- (5H-chromeno [3,4-c]pyridin-8- yl)-2- phenylacetamide::US9663529, Example I-6

SMILES N[C@@H](C(=O)Nc1ccc-2c(OCc3cnccc-23)c1)c1ccccc1

InChI Key InChIKey=CGXOKVWAHQLXGW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 330067   

TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM330067(US9663529, Example I-6 | (R)-2-amino-N- (5H-chrome...)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of ROCK2 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM330067(US9663529, Example I-6 | (R)-2-amino-N- (5H-chrome...)
Affinity DataIC50: 9.43nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM330067(US9663529, Example I-6 | (R)-2-amino-N- (5H-chrome...)
Affinity DataIC50: 16nMAssay Description:Inhibition of ROCK1 (unknown origin) using FITC-AHA-AKRRRLSSLRA-OH as substrate by caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed