BDBM331161 3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrolo[2,3-c]pyridine::US9725446, Compound A20

SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3c[nH]c4cnccc34)c2c1

InChI Key InChIKey=QEKJMVPBZHTKHP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 331161   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM331161(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: <1.00E+3nMAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetTGF-beta receptor type-1(Human)
Merck Patent

US Patent
LigandPNGBDBM331161(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: <1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetSerine/threonine-protein kinase TBK1(Human)
Merck Patent

US Patent
LigandPNGBDBM331161(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


LigandPNGBDBM331161(3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]p...)
Affinity DataIC50: <1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent