BDBM331842 7-[4-(3-t-butoxycarbonyl-2-hydroxypropyl)oxy-2-methoxyphenyl]-8-(5-fluoro-2-methylphenoxymethyl)-1,3,3-trimethyl-3,4-dihydro-1H-quinoxalin-2-one::US10189796, Compound 7-2::US10435379, Compound 7-2

SMILES COc1cc(OCC(O)CC(=O)OC(C)(C)C)ccc1-c1ccc2NC(C)(C)C(=O)N(C)c2c1COc1cc(F)ccc1C

InChI Key InChIKey=NNSNQZKFSYVKFX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331842   

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331842(7-[4-(3-t-butoxycarbonyl-2-hydroxypropyl)oxy-2-met...)
Affinity DataIC50: 83nMAssay Description:o evaluate the action of the present compounds as a GR agonist, IL-6 production inhibitory action in human corneal epithelial cell line after LPS sti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetInterleukin-6(Human)
Santen Pharmaceutical

US Patent
LigandPNGBDBM331842(7-[4-(3-t-butoxycarbonyl-2-hydroxypropyl)oxy-2-met...)
Affinity DataIC50: 83nMAssay Description:1) The subcultured HCE-T was recovered and the cells were seeded at 2.0×104 cells/0.1 mL/well in a 96-well flat bottom culture plate.2) After culturi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent