BDBM332236 N-(2-Hydroxy-ethyl)-1-[5-(3-methoxyphenyl)-pyrimidin-2-yl]-N-methyl-spiro[1,2-dihydro-indole-3,1''-cyclopropane]-6-carboxylic acid amide::US10189854, Compound 197::US10189854, Compound 266

SMILES COc1cccc(c1)-c1cnc(nc1)N1CC2(CC2)c2ccc(cc12)C(=O)N(C)CCO

InChI Key InChIKey=MDIOSBSVWPBGCH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332236   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Gruenenthal

US Patent
LigandPNGBDBM332236(US10189854, Compound 197 | N-(2-Hydroxy-ethyl)-1-[...)
Affinity DataIC50: 100nMAssay Description:The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Gruenenthal

US Patent
LigandPNGBDBM332236(US10189854, Compound 197 | N-(2-Hydroxy-ethyl)-1-[...)
Affinity DataIC50: 100nMAssay Description:The inhibiting effect of the compounds on the enzyme activity of human PDE4B1 was measured by the quantification of 5′-adenosine monophosphate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent