BDBM33254 phthalazine-based compound, 5

SMILES NCc1ccc(Nc2nnc(Nc3ccc(cc3)C3=NCCN3)c3ccccc23)cc1

InChI Key InChIKey=DQOOPKPLAFDHEQ-UHFFFAOYSA-N

Data  5 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 33254   

TargetGenome polyprotein [1393-1439,E1407V]/[1476-1660,R1508K,A1566M](Dengue virus 1(Hawaii))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50:  1.23E+4nMpH: 7.5 T: 37°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGenome polyprotein [1066-1250,R1182K]/[1394-1440,K1405R,D1408E](Dengue virus 2)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50:  5.80E+3nM Kd:  1.86E+4nMpH: 7.5 T: 37°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGenome polyprotein [1394-1440]/[1476-1660,T1585M](Dengue virus 3 (strain S221/03))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGenome polyprotein [1394-1440]/[1476-1660](Dengue virus 4 (H241))
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50:  8.20E+3nMAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGenome polyprotein [1424-1463]/[1502-1685](WNV)
Novartis Institute For Tropical Diseases

LigandPNGBDBM33254(phthalazine-based compound, 5)
Affinity DataIC50:  1.06E+4nM Kd:  1.00E+5nMpH: 7.5 T: 37°CAssay Description:Inhibitors were assayed in a 96-well plate format. Typically, protease was preincubated with concentrations of test compounds at 37 deg C for 30 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed