BDBM332544 (E)-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-7-(2-ethoxyethoxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide ::US10196365, Compound 12

SMILES CCOCCOc1cc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

InChI Key InChIKey=XPZGTHUXSPUGHN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 332544   

TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 332544BDBM332544(US10196365, Compound 12 | (E)-N-(4-(3-chloro-4-(py...)
Affinity DataIC50: 1nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 332544BDBM332544(US10196365, Compound 12 | (E)-N-(4-(3-chloro-4-(py...)
Affinity DataIC50: 10.2nMAssay Description:The kinase analysis in vitro was performed using the HTRF kinEASE TK kit of Invitrogen Co., the procedure steps were carried out according to instruc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Arromax Pharmatech

US Patent
LigandChemical structure of BindingDB Monomer ID 332544BDBM332544(US10196365, Compound 12 | (E)-N-(4-(3-chloro-4-(py...)
Affinity DataIC50: 53.9nMAssay Description:The kinase analysis in vitro was performed using the HTRF kinEASE TK kit of Invitrogen Co., the procedure steps were carried out according to instruc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent