BDBM332553 (2E)-3-(4-bromophenyl)-1-{2-[(4-fluorophenyl)methyl]-2,7-diazaspiro[3.5]non-7-yl}prop-2-en-1-one::US10196369, Compound C8

SMILES CCc1c(N2CCN(C(=O)c3cnc4ccccc4c3O)CC2)c(=O)n2nc(C3=CCOCC3)nc2n1CC(=O)Nc1ccc(C(F)(F)F)cc1Cl

InChI Key InChIKey=UOBSCHKLPFVGDF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332553   

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Danatlas Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 332553BDBM332553(US20260015358, Example 266)
Affinity DataIC50: 100nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRISMC) Center Affiliation: The Scripps Research Institute, TS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details US Patent

TargetBifunctional 3'-5' exonuclease/ATP-dependent helicase WRN(Human)
Danatlas Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 332553BDBM332553(US20260015358, Example 266)
Affinity DataIC50: 129nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed