BDBM332706 US10196378, Compound C09::US10196378, Compound C10

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccc4cccnc4c3)cc2)n(n1)-c1ccc2ncccc2c1

InChI Key InChIKey=DQLDULIEUKHCJI-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 332706   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332706(US10196378, Compound C09 | US10196378, Compound C1...)
Affinity DataKi:  0.640nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [Y253F](Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332706(US10196378, Compound C09 | US10196378, Compound C1...)
Affinity DataKi:  2.5nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332706(US10196378, Compound C09 | US10196378, Compound C1...)
Affinity DataKi:  3.30nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1 [Y253F](Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332706(US10196378, Compound C09 | US10196378, Compound C1...)
Affinity DataKi:  7.60nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332706(US10196378, Compound C09 | US10196378, Compound C1...)
Affinity DataKi:  143nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332706(US10196378, Compound C09 | US10196378, Compound C1...)
Affinity DataKi:  345nMAssay Description:The biochemical assays were carried out using the non-phosphorylated kinase domain of c-Abl, Bcr-Abl in Ba/F3 cells is in the phosphorylated state.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM332706(US10196378, Compound C09 | US10196378, Compound C1...)
Affinity DataIC50:  719nMAssay Description:Inhibition of NanoLuc-tagged ABL1 wild type (unknown origin) expressed in HEK293 cells by NanoBRET TE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed