BDBM334036 9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(1,3-oxazol-4- ylcarbonyl)pyrrolidin-3-yl]oxy}- 9H-purine::US9730940, Compound 2-136

SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)c3cocn3)ncnc12)-c1cnc(C)nc1

InChI Key InChIKey=GTDNUYQEEDHPIM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 334036   

LigandPNGBDBM334036(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(1,...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM334036(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(1,...)
Affinity DataIC50: 14nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

LigandPNGBDBM334036(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(1,...)
Affinity DataIC50: 94nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
LigandPNGBDBM334036(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(1,...)
Affinity DataIC50: 600nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-CD79b antibody-induced CD69 expression preincubated for 60 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed