BDBM335640 US9732093, Compound 149::tert-Butyl [2-({2-[3-(5-aminopyrazin-2- yl)-6-cyclobutyl-2- fluorophenoxy]pyrimidin-4- yl}amino)ethyl]carbamate

SMILES CC(C)(C)OC(=O)NCCNc1cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)ncn1

InChI Key InChIKey=JPMKRRHPRXNEOO-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335640   

TargetFlap endonuclease 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM335640(US9732093, Compound 149 | tert-Butyl [2-({2-[3-(5-...)
Affinity DataKi:  1.30nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent


TargetFlap endonuclease 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM335640(US9732093, Compound 149 | tert-Butyl [2-({2-[3-(5-...)
Affinity DataKi:  1.30nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent