BDBM336815 6-((((R)-2-oxopyrrolidin-3- yl)amino)methyl)-2-(4-(4- (trifluoromethyl)phenoxy)cyclohex- 1-en-1-yl)pyrimidine-4-carboxamide::US9745287, Compound 56

SMILES NC(=O)c1cc(CN[C@@H]2CCNC2=O)nc(n1)C1=CCC(CC1)Oc1ccc(cc1)C(F)(F)F

InChI Key InChIKey=MJVPYKXLSAXOSB-UHUGOGIASA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336815   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336815(6-((((R)-2-oxopyrrolidin-3- yl)amino)methyl)-2-(4-...)
Affinity DataKi:  117nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336815(6-((((R)-2-oxopyrrolidin-3- yl)amino)methyl)-2-(4-...)
Affinity DataIC50:  544nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent