BDBM336816 (S)-3-(((6-((S)-1,2- dihydroxyethyl)-2-(4-(4- (trifluoromethoxy)phenoxy)phenyl)pyrimidin- 4-yl)methyl)-amino)pyrrolidin-2-one::US9745287, Compound 40

SMILES OC[C@@H](O)c1cc(CN[C@H]2CCNC2=O)nc(n1)-c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=PTTGTRYLSFIPJH-PZJWPPBQSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336816   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336816((S)-3-(((6-((S)-1,2- dihydroxyethyl)-2-(4-(4- (tri...)
Affinity DataKi:  2.68E+3nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336816((S)-3-(((6-((S)-1,2- dihydroxyethyl)-2-(4-(4- (tri...)
Affinity DataIC50:  1.56E+3nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent