BDBM336817 (S)-4-((6-(1,2-dihydroxyethyl)- 2-(4-(4-(trifluoromethoxy)- phenoxy)phenyl)pyrimidin-4- yl)methyl)piperazin-2-one::US9745287, Compound 41

SMILES OC[C@@H](O)c1cc(CN2CCNC(=O)C2)nc(n1)-c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=HTZGXLVJGBQQPM-OAQYLSRUSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 336817   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336817((S)-4-((6-(1,2-dihydroxyethyl)- 2-(4-(4-(trifluoro...)
Affinity DataKi:  875nMAssay Description:Cells Manual Electrophysiology: The hNav1.7 expressing HEK-293 cells are plated on 35 mm culture dishes pre-coated with poly-D-lysine in standard DME...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Purdue Pharma

US Patent
LigandPNGBDBM336817((S)-4-((6-(1,2-dihydroxyethyl)- 2-(4-(4-(trifluoro...)
Affinity DataIC50:  1.19E+3nMAssay Description:Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent