BDBM337676 3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1-[4-(2-oxoimidazolidin-1-yl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid::US9751843, 51

SMILES Cc1c(cccc1C(F)(F)F)CN2C(=O)C(=CN(C2=O)c3ccc(cc3)N4CCNC4=O)C(=O)O

InChI Key InChIKey=MUZPDPKTCZSNCS-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 337676   

TargetChymase(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 337676BDBM337676(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human recombinant chymase using Abz-HPFHL-Lys(Dnp)-NH2 as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 337676BDBM337676(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Affinity DataIC50: 45nMAssay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetChymase(Canis lupus familiaris)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 337676BDBM337676(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Affinity DataIC50: 483nMAssay Description:Inhibition of recombinant dog chymase using Abz-HPFHL-Lys(Dnp)-NH2 as substrate by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed