BDBM341516 (R)-N-(4-ethyl-5-(2-(5-(3-fluoro-5-methylpyridin-2-yl)-2-methyl-7,8-dihydro-[1,3,4]thiadiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(5H)-yl)-2-oxoethoxy)pyrimidin-2-yl)methanesulfonamide::US9765092, Example 1.31.19

SMILES CCc1nc(NS(C)(=O)=O)ncc1OCC(=O)N1CCc2nc3sc(C)nn3c2[C@@H]1c1ncc(C)cc1F

InChI Key InChIKey=XWWBHVQKOQJTTO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341516   

TargetTryptophan 5-hydroxylase 1(Human)
Actelion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 341516BDBM341516(US9765092, Example 1.31.19 | (R)-N-(4-ethyl-5-(2-(...)
Affinity DataIC50: 51nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
US Patent