BDBM341632 1-((5R)-5-(4-chloro-2-fluorophenyl)-4a,5-dihydro-thiazolo[2',3':2,3]imidazo[4,5-c]pyridin-6(7H)-yl)-2-(2-chloro-4-morpholinophenoxy)ethanone::US9765092, Example 6.4.2

SMILES O=C(COc1ccc(N2CCOCC2)cc1Cl)N1CC=C2N=C3SC=CN3C2[C@H]1c1ccc(Cl)cc1F

InChI Key InChIKey=PBHSGICFDXAPOM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341632   

TargetTryptophan 5-hydroxylase 1(Human)
Actelion Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 341632BDBM341632(US9765092, Example 6.4.2 | 1-((5R)-5-(4-chloro-2-f...)
Affinity DataIC50: 4nMAssay Description:To generate the enzyme, full length human TPH1 is cloned into the plasmid pET20b(+) (Novagen) and expressed in E. coli. The bacterial cells are ruptu...More data for this Ligand-Target Pair
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Date in BDB:
7/29/2019
Entry Details
US Patent