BDBM342194 4-[2-(4-aminopiperidin-1-yl)-5-(6- ethoxypyridin-3-yl)-1-methyl-6- oxopyrimidin-4-yl]-2- fluorobenzonitrile::US10207999, Example 94::US10328077, Example 94::US10548896, Example 94::US10849898, Example 94::US10960005, Example 94::US11084793, Example 94::US9771329, Example 94::US9776974, Example 94

SMILES CCOc1ccc(cn1)-c1c(nc(N2CCC(N)CC2)n(C)c1=O)-c1ccc(C#N)c(F)c1

InChI Key InChIKey=XZMVBFNPAKMGEM-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 342194   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2022
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:The enzymatic assay of LSD-1 activity is based on Tnne Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD1 demethylase activity. E. coli expressed full-length human LSD1 (Accession number...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:To analyze LSD1 inhibitor efficacy in cells, a CD11b flow cytometry assay was performed. LSD1 inhibition induces CD11b expression in THP-1 (AML) cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2020
Entry Details
US Patent

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM342194(US9771329, Example 94 | 4-[2-(4-aminopiperidin-1-y...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent