BDBM343644 US10442803, Example 243::US11091484, Example 243::US9777003, Example 243::tert-Butyl 3-((6-benzyl-1,7-dimethyl-6H- pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyridin- 4-ylamino)methyl)azetidine-1-carboxylate

SMILES Cc1cc2c(cc(NCC3CN(C3)C(=O)OC(C)(C)C)c3nnc(C)n23)n1Cc1ccccc1

InChI Key InChIKey=NAAGLLLJBQNDFQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 343644   

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM343644(tert-Butyl 3-((6-benzyl-1,7-dimethyl-6H- pyrrolo[2...)
Affinity DataIC50: 100nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Incyte

US Patent
LigandPNGBDBM343644(tert-Butyl 3-((6-benzyl-1,7-dimethyl-6H- pyrrolo[2...)
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Incyte

US Patent
LigandPNGBDBM343644(tert-Butyl 3-((6-benzyl-1,7-dimethyl-6H- pyrrolo[2...)
Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent
LigandPNGBDBM343644(tert-Butyl 3-((6-benzyl-1,7-dimethyl-6H- pyrrolo[2...)
Affinity DataIC50: 550nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details
US Patent

TargetBromodomain-containing protein 4 [342-460](Human)
Incyte

US Patent
LigandPNGBDBM343644(tert-Butyl 3-((6-benzyl-1,7-dimethyl-6H- pyrrolo[2...)
Affinity DataIC50: 1.00E+3nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [42-168](Human)
Incyte

US Patent
LigandPNGBDBM343644(tert-Butyl 3-((6-benzyl-1,7-dimethyl-6H- pyrrolo[2...)
Affinity DataIC50: 5.50E+3nMAssay Description:BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent