BDBM344104 US10370387, Example 88::US11161855, Example 88::US9777017, Example 88::US9908895, Example 88

SMILES CC(C)OC(=O)NC[C@H]1CC[C@@H](CC1)n1c(CC#N)nc2cnc3ccsc3c12

InChI Key InChIKey=GQOXNEHZBXBKPO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 344104   

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte Holdings

US Patent
LigandPNGBDBM344104(US9777017, Example 88 | US9908895, Example 88 | US...)
Affinity DataIC50: 100nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM344104(US9777017, Example 88 | US9908895, Example 88 | US...)
Affinity DataIC50: 100nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM344104(US9777017, Example 88 | US9908895, Example 88 | US...)
Affinity DataIC50: 100nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte Holdings

US Patent
LigandPNGBDBM344104(US9777017, Example 88 | US9908895, Example 88 | US...)
Affinity DataIC50: 100nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Incyte

US Patent
LigandPNGBDBM344104(US9777017, Example 88 | US9908895, Example 88 | US...)
Affinity DataIC50: 5.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM344104(US9777017, Example 88 | US9908895, Example 88 | US...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Incyte

US Patent
LigandPNGBDBM344104(US9777017, Example 88 | US9908895, Example 88 | US...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandPNGBDBM344104(US9777017, Example 88 | US9908895, Example 88 | US...)
Affinity DataIC50: 5.00E+5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent