BDBM345137 1-(4-((2-((7-Methyl-1H-indazol-5-yl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea::US9783556, Example 9

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(C)c4[nH]ncc4c3)n2)c2ccccc12)[Si](C)(C)C

InChI Key InChIKey=KOKCRILDELZVDH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 345137   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM345137(1-(4-((2-((7-Methyl-1H-indazol-5-yl)amino)pyrimidi...)
Affinity DataIC50: 135nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
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US Patent
LigandPNGBDBM345137(1-(4-((2-((7-Methyl-1H-indazol-5-yl)amino)pyrimidi...)
Affinity DataIC50: 358nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM345137(1-(4-((2-((7-Methyl-1H-indazol-5-yl)amino)pyrimidi...)
Affinity DataIC50: 520nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM345137(1-(4-((2-((7-Methyl-1H-indazol-5-yl)amino)pyrimidi...)
Affinity DataIC50: 1.00E+4nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent