BDBM345140 3-Methoxy-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)benzamide::US9783556, Example 12

SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)[Si](C)(C)C)c4ccccc34)n2)cc(c1)C(=O)NCCN1CCOCC1

InChI Key InChIKey=BWVGZIFGIUHNAE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 345140   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Respivert

US Patent
LigandPNGBDBM345140(3-Methoxy-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Respivert

US Patent
LigandPNGBDBM345140(3-Methoxy-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p...)
Affinity DataIC50: 17nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Respivert

US Patent
LigandPNGBDBM345140(3-Methoxy-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p...)
Affinity DataIC50: 142nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Respivert

US Patent
LigandPNGBDBM345140(3-Methoxy-N-(2-morpholinoethyl)-5-((4-((4-(3-(1-(p...)
Affinity DataIC50: 461nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent