BDBM345141 1-(4-((2-((3-Methoxy-5-(2-morpholinoethoxy)phenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(p-tolyl)-3-(trimethylsilyl)-1H-pyrazol-5-yl)urea::US9783556, Example 13

SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)[Si](C)(C)C)c4ccccc34)n2)cc(OCCN2CCOCC2)c1

InChI Key InChIKey=JERWIKUDUYPNOF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 345141   

TargetTyrosine-protein kinase SYK(Human)
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US Patent
LigandPNGBDBM345141(1-(4-((2-((3-Methoxy-5-(2-morpholinoethoxy)phenyl)...)
Affinity DataIC50: 106nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM345141(1-(4-((2-((3-Methoxy-5-(2-morpholinoethoxy)phenyl)...)
Affinity DataIC50: 170nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM345141(1-(4-((2-((3-Methoxy-5-(2-morpholinoethoxy)phenyl)...)
Affinity DataIC50: 320nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
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US Patent
LigandPNGBDBM345141(1-(4-((2-((3-Methoxy-5-(2-morpholinoethoxy)phenyl)...)
Affinity DataIC50: 1.00E+3nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2019
Entry Details
US Patent