BDBM346172 (4S*,5S*)-3-(2′-amino-2-morpholino-4′-(trifluoromethyl)-[4,5′-bipyrimidin]-6-yl)-4-ethyl-5-(4-methoxyphenyl)oxazolidin-2-one::US10202371, Example 2

SMILES CC[C@H]1[C@@H](OC(=O)N1c1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1C(F)(F)F)c1ccc(OC)cc1

InChI Key InChIKey=HFELRNZIXKMMLK-ICSRJNTNSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 346172   

LigandPNGBDBM346172((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...)
Affinity DataIC50:  78nMAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346172((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...)
Affinity DataIC50:  96nMAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346172((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...)
Affinity DataIC50:  27nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346172((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...)
Affinity DataIC50:  105nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM346172((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...)
Affinity DataIC50:  2.80E+3nMAssay Description:TR-FRET assays for protein kinases uses a long-lifetime lanthanide Terbium or Europium chelates as the donor species which overcome interference by c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346172((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...)
Affinity DataIC50:  1.07E+3nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346172((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...)
Affinity DataIC50:  751nMAssay Description:AlphaScreen (Amplified Luminescent Proximity Homogeneous Assay, ALPHA, Perkin Elmer) is a non-radioactive bead-based proximity assay technology to st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM346172((4S*,5S*)-3-(2′-amino-2-morpholino-4′-...)
Affinity DataIC50:  5.80E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent