BDBM346441 US10202378, Example 54::isobutyl 4-[(3R)-3-hydroxy-3-(5-methylisoxazol-3-yl)but-1-ynyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-3-carboxylate

SMILES CC(C)COC(=O)c1c[nH]c2c1c(cn(C)c2=O)C#C[C@@](C)(O)c1cc(C)on1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 346441   

TargetTranscription initiation factor TFIID subunit 1 [1381-1497](Homo sapiens (human))
Genentech

US Patent
LigandPNGBDBM346441(US10202378, Example 54 | isobutyl 4-[(3R)-3-hydrox...)
Affinity DataIC50:  179nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1504-1635](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM346441(US10202378, Example 54 | isobutyl 4-[(3R)-3-hydrox...)
Affinity DataIC50:  122nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent