BDBM347311 N-(6-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)-2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)acetamide hydrochloride::US9789100, Example 2

SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cnc(OCC)c(c2)C(F)(F)F)c(F)c1

InChI Key InChIKey=LALDAJOBEOZWHQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 347311   

LigandPNGBDBM347311(N-(6-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)-2-(4-...)
Affinity DataIC50: 100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandPNGBDBM347311(N-(6-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)-2-(4-...)
Affinity DataIC50: 300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandPNGBDBM347311(N-(6-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)-2-(4-...)
Affinity DataIC50: 300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent