BDBM347321 N-(4-Cyano-3-(trifluoro-methyl)phenyl)-2-(4-(5-ethoxy-6-oxo-1,6-dihydro-pyridin-3-yl)-2-fluorophenyl)acetamide::US9789100, Example 9

SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2ccc(C#N)c(c2)C(F)(F)F)c(F)c1

InChI Key InChIKey=YJSQUYQAEQTJDA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 347321   

LigandPNGBDBM347321(N-(4-Cyano-3-(trifluoro-methyl)phenyl)-2-(4-(5-eth...)
Affinity DataIC50: 100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandPNGBDBM347321(N-(4-Cyano-3-(trifluoro-methyl)phenyl)-2-(4-(5-eth...)
Affinity DataIC50: 300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

LigandPNGBDBM347321(N-(4-Cyano-3-(trifluoro-methyl)phenyl)-2-(4-(5-eth...)
Affinity DataIC50: 300nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent