BDBM347464 N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulfonyl)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)ureido)-2-methoxyphenyl)methanesulfonamide::US10435361, Example 5::US9790174, Example 5

SMILES CNc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(c4)S(=O)(=O)C4CC4)n3)c3ccccc23)c1OC)C(C)(C)C

InChI Key InChIKey=YOMMMGHYVKDIIV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 347464   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347464(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulf...)
Affinity DataIC50: 48nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347464(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulf...)
Affinity DataIC50: 48nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Respivert

US Patent
LigandPNGBDBM347464(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulf...)
Affinity DataIC50: 271nMAssay Description:The following two assay variants can be used for determination of p38 MAPKα inhibition.Method 1The inhibitory activities of test compounds again...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Respivert

US Patent
LigandPNGBDBM347464(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulf...)
Affinity DataIC50: 271nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347464(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulf...)
Affinity DataIC50: 1.17E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347464(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulf...)
Affinity DataIC50: 1.17E+3nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347464(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulf...)
Affinity DataIC50: 2.87E+3nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347464(N-(5-(tert-Butyl)-3-(3-(4-((2-((3-(cyclopropylsulf...)
Affinity DataIC50: 2.87E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent