BDBM347470 N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methoxy-5-(2-(2-(2-methoxyethoxy)ethoxy)-ethoxy)phenyl)amino)pyridin-4-yl)oxy)naphthalen-1-yl)ureido)phenyl)-methanesulfonamide::US10435361, Example 11::US9790174, Example 11

SMILES CNc1cc(cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cc(OC)cc(OCCOCCOCCOC)c4)c3)c3ccccc23)c1OC)C(C)(C)C

InChI Key InChIKey=CKVWFKWUVXFXPC-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 347470   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347470(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50: 21nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347470(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50: 21nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347470(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50: 124nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347470(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50: 124nMAssay Description:The following two assay variants can be used for determination of p38 MAPKα inhibition.Method 1The inhibitory activities of test compounds again...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347470(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50: 193nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetTyrosine-protein kinase SYK(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347470(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50: 193nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347470(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50: 1.22E+4nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
Topivert Pharma

US Patent
LigandPNGBDBM347470(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50: 1.22E+4nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
US Patent