BDBM349307 US10207991, Ex. Cpd. No. 4::US10611728, Example Compound 4::US11691947, Example 4

SMILES C[C@H](CCc1ccc(Cl)c(Cl)c1)N1Cc2ccc(cc2C1)C(F)(F)F

InChI Key InChIKey=PSSRUTSUVLVFTJ-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 349307   

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349307(US10207991, Ex. Cpd. No. 4 | US10611728, Example C...)
Affinity DataKi:  2.20nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349307(US10207991, Ex. Cpd. No. 4 | US10611728, Example C...)
Affinity DataKi:  2.20nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349307(US10207991, Ex. Cpd. No. 4 | US10611728, Example C...)
Affinity DataKi:  2.20nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Rat)
Cognition Therapeutics

US Patent
LigandPNGBDBM349307(US10207991, Ex. Cpd. No. 4 | US10611728, Example C...)
Affinity DataKi:  2.20nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349307(US10207991, Ex. Cpd. No. 4 | US10611728, Example C...)
Affinity DataKi:  33nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349307(US10207991, Ex. Cpd. No. 4 | US10611728, Example C...)
Affinity DataKi:  33nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Cognition Therapeutics

US Patent
LigandPNGBDBM349307(US10207991, Ex. Cpd. No. 4 | US10611728, Example C...)
Affinity DataKi:  33nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349307(US10207991, Ex. Cpd. No. 4 | US10611728, Example C...)
Affinity DataKi:  33nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent