BDBM349541 US10207991, Ex. Cpd. No. 57::US10611728, Example Compound 57::US11691947, Example 57

SMILES CN(C)C(=O)c1cccc2CN(Cc12)C(C)(C)CCc1ccc(O)c(OC(F)(F)F)c1

InChI Key InChIKey=FDCGTJLLXGZZIX-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 349541   

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataKi:  95nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Rat)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataKi:  95nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataKi:  95nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma intracellular receptor 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataKi:  95nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataKi:  700nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataKi:  700nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataKi:  700nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataKi:  700nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349541(US10207991, Ex. Cpd. No. 57 | US10611728, Example ...)
Affinity DataIC50: 5.00E+3nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent