BDBM349638 2-(2,6-Difluorophenyl)-2-(1-((1,3,5-trimethyl-1H-pyrazol-4-yl) sulfonyl)piperidin-4-ylidene)acetonitrile::US10208016, Compound of Example 8::US10335402, Example 8

SMILES [#6]-c1nn(-[#6])c(-[#6])c1S(=O)(=O)[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](\C#N)-c1c(F)cccc1F

InChI Key InChIKey=GHGXHUXOVJIAJN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349638   

Target5-hydroxytryptamine receptor 2A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349638(2-(2,6-Difluorophenyl)-2-(1-((1,3,5-trimethyl-1H-p...)
Affinity DataIC50: 5.43E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349638(2-(2,6-Difluorophenyl)-2-(1-((1,3,5-trimethyl-1H-p...)
Affinity DataIC50: 5.43E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349638(2-(2,6-Difluorophenyl)-2-(1-((1,3,5-trimethyl-1H-p...)
Affinity DataIC50: 5.43E+3nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent