BDBM349640 2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-3-methylpiperidin-4-ylidene) acetonitrile::US10208016, Compound of Example 10::US10335402, Example 10

SMILES CC1CN(CC\C1=C(/C#N)c1ccc(Cl)cc1)S(=O)(=O)c1c(C)n[nH]c1C

InChI Key InChIKey=UHAAKMVWUJVWNK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349640   

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349640(2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-...)
Affinity DataIC50: 470nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349640(2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-...)
Affinity DataIC50: 470nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349640(2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-...)
Affinity DataIC50: 470nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent