BDBM349643 4-(1-(4-Chlorophenypethylidene)-1-((3,5-dimethyl-1H-pyrazol-4-yl) sulfonyl)piperidine::US10208016, Compound of Example 13::US10335402, Example 13

SMILES CC(=C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1

InChI Key InChIKey=AIRJRZFTFLCUKL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349643   

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349643(4-(1-(4-Chlorophenypethylidene)-1-((3,5-dimethyl-1...)
Affinity DataIC50: 760nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349643(4-(1-(4-Chlorophenypethylidene)-1-((3,5-dimethyl-1...)
Affinity DataIC50: 760nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349643(4-(1-(4-Chlorophenypethylidene)-1-((3,5-dimethyl-1...)
Affinity DataIC50: 760nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent