BDBM349650 4-((4-Chloro-3-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl) sulfonyl)piperidine::US10208016, Compound of Example 20::US10335402, Example 20

SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)=C(F)c1ccc(Cl)c(F)c1

InChI Key InChIKey=YAXYBAJRIAAJBG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 349650   

TargetProkineticin receptor 1(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349650(4-((4-Chloro-3-fluorophenyl)fluoromethylene)-1-((3...)
Affinity DataIC50: 190nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349650(4-((4-Chloro-3-fluorophenyl)fluoromethylene)-1-((3...)
Affinity DataIC50: 190nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM349650(4-((4-Chloro-3-fluorophenyl)fluoromethylene)-1-((3...)
Affinity DataIC50: 190nMAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent