BDBM350161 (1S,3R)-3-[8-amino-5- chloro-1-(4-{(1R)-1-[3- (difluoromethyl)phenyl]-1- hydroxyethyl}phenyl)imidazo [1,5-a]pyrazin-3-yl]-1-(1- methylethyl)cyclopentane- carboxylic acid::US10208047, Example 29

SMILES CC(C)[C@@]1(CC[C@H](C1)c1nc(-c2ccc(cc2)[C@@](C)(O)c2cccc(c2)C(F)F)c2c(N)ncc(Cl)n12)C(O)=O

InChI Key InChIKey=XIPWRIMFDHRJSS-CUROCWSNSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 350161   

TargetTyrosine-protein kinase BTK(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM350161((1S,3R)-3-[8-amino-5- chloro-1-(4-{(1R)-1-[3- (dif...)
Affinity DataIC50:  2.80nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent