BDBM350389 4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile::US10208066, Compound 2::US10208066, Compound 80::US10611777, Compound 2

SMILES CC(Nc1ncnc(N)c1C#N)c1cc2ncc(Cl)n2nc1-c1ccccc1

InChI Key InChIKey=WKDBRCUUDXLTIM-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 350389   

LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  1nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  168nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  323nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50: >1.00E+3nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  0.5nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  59nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  272nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  1nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  168nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  323nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50: >1.00E+3nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  87nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM350389(4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyri...)
Affinity DataIC50:  168nMAssay Description:Briefly, the Transcreener KINASE Assay was designed as a simple two-part, endpoint assay as follows:1) Preparation of 25 uL kinase reaction: the 25 u...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent