BDBM351682 N-(4-cyano-3-(pyrazin-2-yl)thiophen-2-yl)-2-(quinolin-5-yl)acetamide::US9796706, Compound 126

SMILES O=C(Cc1cccc2ncccc12)Nc1scc(C#N)c1-c1cnccn1

InChI Key InChIKey=OIWWCBDLNQMJED-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 351682   

TargetMitogen-activated protein kinase 8(Human)
Imago Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 351682BDBM351682(US9796706, Compound 126 | N-(4-cyano-3-(pyrazin-2-...)
Affinity DataIC50: 100nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 10(Human)
Imago Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 351682BDBM351682(US9796706, Compound 126 | N-(4-cyano-3-(pyrazin-2-...)
Affinity DataIC50: 100nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 9(Human)
Imago Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 351682BDBM351682(US9796706, Compound 126 | N-(4-cyano-3-(pyrazin-2-...)
Affinity DataIC50: 5.05E+3nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent