BDBM351732 N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thiophen-2-yl)-2-(2-oxo-7-(trifluoromethyl)-1,6-naphthyridin-1(2H)-yl)acetamide::US9796706, Compound 176

SMILES Cn1cnc(n1)-c1c(Cl)csc1NC(=O)Cn1c2cc(ncc2ccc1=O)C(F)(F)F

InChI Key InChIKey=GNOUFYLAXAIVPV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 351732   

TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM351732(N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thio...)
Affinity DataIC50: <100nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM351732(N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thio...)
Affinity DataIC50: <100nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Imago Pharmaceuticals

US Patent
LigandPNGBDBM351732(N-(4-chloro-3-(1-methyl-1H-1,2,4-triazol-3-yl)thio...)
Affinity DataIC50: <100nMAssay Description:(1) Assay buffer #1 with 0.0025% Tween and 1 mM DTT was prepared using JNK buffer stock solution.(2) Assay buffer #2 with 0.025% BSA was prepared usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent