BDBM354276 1-(1-(4-(Dimethylphosphoryl)phenyl)-3-isopropyl-1H-pyrazol-5-yl)-3-(4-((2-(phenylamino)-pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9796742, Example 4

SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccccc4)n3)c3ccccc23)n(n1)-c1ccc(cc1)P(C)(C)=O

InChI Key InChIKey=KYCKVFRIBMZEAX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354276   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM354276(1-(1-(4-(Dimethylphosphoryl)phenyl)-3-isopropyl-1H...)
Affinity DataIC50: 12nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
9/23/2019
Entry Details
US Patent

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM354276(1-(1-(4-(Dimethylphosphoryl)phenyl)-3-isopropyl-1H...)
Affinity DataIC50: 220nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent