BDBM354393 (S)-7-(2-ethyl-3- ((4-(4- fluorophenyl) thiazol-2- yl)(methyl)amino) imidazo[1,2- b]pyridazin-6- yl)tetrahydro-1H- oxazolo[3,4- a]pyrazin-3(5H)- one::US9796719, Compound 61

SMILES CCc1nc2ccc(nn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCN2[C@H](COC2=O)C1

InChI Key InChIKey=WKJBCVILBIFOCI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354393   

LigandPNGBDBM354393((S)-7-(2-ethyl-3- ((4-(4- fluorophenyl) thiazol-2-...)
Affinity DataIC50: 55nMAssay Description:Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
US Patent

TargetAutotaxin(Human)
Galapagos

US Patent
LigandPNGBDBM354393((S)-7-(2-ethyl-3- ((4-(4- fluorophenyl) thiazol-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound IC50 values are determined in a fluorescent hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using the fluorogenic autotax...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2019
Entry Details
US Patent